25-Hydroxyvitamin D Levels and the Risk of Stroke

A Prospective Study and Meta-analysis

Stroke.ahajournals.org: Qi Sun, MD, ScD; An Pan, PhD; Frank B. Hu, MD, PhD; JoAnn E. Manson, MD, DrPH; Kathryn M. Rexrode, MD, MPH., March 22, 2012.

Background and Purpose—Despite evidence suggesting that vitamin D deficiency may lead to elevated cardiovascular disease risk, results regarding the association of 25-hydroxyvitamin D (25[OH]D) levels with stroke risk are inconclusive. We aimed to examine this association in a prospective study in women and to summarize all existing data in a meta-analysis.

Methods—We measured 25(OH)D levels among 464 women who developed ischemic stroke and an equal number of control subjects who were free of stroke through 2006 in the Nurses’ Health Study (NHS). We searched MEDLINE and EMBASE for articles published through March 2011 that prospectively evaluated 25(OH)D levels in relation to stroke.Read More