A critical evaluation of statistical approaches to examining the role of growth trajectories in the developmental origins of health and disease

Int. J. Epidemiol: September 14, 2013

The developmental origins of health and disease hypothesis suggests that small birth size in conjunction with rapid compensatory childhood growth might yield a greater risk of developing chronic diseases in later life. For example, there is evidence that people who developed coronary heart disease and diabetes experienced different growth trajectories from those who did not develop these diseases. However, some of the methods used in these articles may have been flawed. We critically evaluate proposed approaches for identifying the growth trajectories distinctive to those developing later disease and identifying critical phases of growth during the early lifecourse. Read More