Accrual by groups in trials with discrete-time survival endpoints

SAGE: 

11/30/12

Background In many fields of science, event status is often recorded in intervals or at discrete points in time and can be investigated in experimental settings. Conducting such trials requires thorough planning before they are actually performed.

Purpose To investigate accrual by groups in a trial with discrete-time survival endpoints and to describe how to choose the number of accrual groups, the size of the accrual groups, and the duration of the trial to achieve a sufficient power level.

Methods In trials with multiple time periods, the event status is recorded at the end of each period, but the event may occur at any time between the time points the measurements are taken. Therefore, time is recorded discretely, but the underlying process is continuous. To find the risk of event occurrence in each time interval, a continuous-time survival function is used and the generalized linear model is applied. Read More