Can POMC methylation be used as an early predictor of metabolic syndrome?

Diabetes Care: November 12, 2013


OBJECTIVE The objectives of this study were to compare early predictive marker of the metabolic syndrome with proopiomelanocortin (POMC) methylation status and to determine the association between birth weight, ponderal index and cord blood methylation status.

RESEARCH DESIGN AND METHODS We collected pregnancy outcome data from pregnant women, cord blood samples at delivery, and blood from children (7-9 years old; n = 90) through a prospective cohort study at Ewha Woman’s University, MokDong Hospital (Seoul, Korea), from 2003 to 2005. POMC methylation was assessed by pyrosequencing. We divided subjects into three groups according to cord blood POMC methylation: the low methylation (< 10th percentile), mid methylation, and high methylation (> 90th percentile) groups. We analyzed the association of POMC methylation status at birth with adiposity and metabolic components using analysis of covariance (ANCOVA) and multiple linear regression analysis. Read More