Characteristics of Clinical Trials Registered in ClinicalTrials.gov, 2007-2010

The Journal of the American Medical Association: May 9, 2012.

Context Recent reports highlight gaps between guidelines-based treatment recommendations and evidence from clinical trials that supports those recommendations. Strengthened reporting requirements for studies registered with ClinicalTrials.gov enable a comprehensive evaluation of the national trials portfolio.

Objective To examine fundamental characteristics of interventional clinical trials registered in the ClinicalTrials.gov database.

Methods A data set comprising 96 346 clinical studies from ClinicalTrials.gov was downloaded on September 27, 2010, and entered into a relational database to analyze aggregate data. Interventional trials were identified and analyses were focused on 3 clinical specialties—cardiovascular, mental health, and oncology—that together encompass the largest number of disability-adjusted life-years lost in the United States. Read More