Circulation Research Thematic Synopsis Diabetes and Obesity

Circulation Research: 9/13/13

Diabetes and obesity have emerged as global epidemics. At present more than 150 million individuals worldwide are living with diabetes and this number is expected to increase by 30% by 2015 and double to 300 million by 2025. In the US alone, there are 18.2 million diabetics (6.3% of the total population) and an estimated 1.3 million new cases are expected to be diagnosed each year.1 Diabetes and insulin resistance, fueled by pandemic obesity, has emerged as an explosive worldwide epidemic that encompasses all ethnicities, economic classes, and age groups.2–4 While diabetes affects several organs systems and disease processes, heart disease is the leading cause of death in diabetics. Both diabetes and cardiovascular disease share a common set of risk factors, and therefore it has been suggested that the two diseases share a similar etiology (the “common soil” hypothesis) and that diabetes and cardiovascular disease share overlapping, if not identical, molecular and cellular mechanisms. Not only does insulin resistance originate from cardiovascular dysfunction, but cardiovascular tissues are the primary targets of diabetes and obesity. Read more