Clinical and genetic determinants of progression of type 2 diabetes: A DIRECT Study

Diabetes Care: November 1, 2013

Objective The rate at which diabetes progresses following diagnosis of type 2 diabetes is highly variable between individuals.

Research Design and Methods We studied 5250 patients with type 2 diabetes using comprehensive electronic medical records on all patients in Tayside, Scotland from 1992 onwards. We investigated the association of clinical, biochemical and genetic factors with the risk of progression of type 2 diabetes from diagnosis to requirement for insulin treatment (defined as insulin treatment or HbA1c ≥8.5%/69 mmol/mol treated with two or more non-insulin diabetes therapies). Read More