Comparative Effectiveness and Safety of Methods of Insulin Delivery and Glucose Monitoring for Diabetes

Ann Intern Med. 10 July 2012.
Patients with diabetes mellitus need information about the effectiveness of innovations in insulin delivery and glucose monitoring.

Purpose: To review how intensive insulin therapy (multiple daily injections [MDI] vs. rapid-acting analogue –based continuous subcutaneous insulin infusion [CSII]) or method of monitoring (self-monitoring of blood glucose [SMBG] vs. real-time continuous glucose monitoring [rt-CGM]) affects outcomes in type 1 and 2 diabetes mellitus.

Data Sources: MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials through February 2012 without language restrictions.

Study Selection: 33 randomized, controlled trials in children or adults that compared CSII with MDI (n = 19), rt-CGM with SMBG (n = 10), or sensor-augmented insulin pump use with MDI and SMBG (n = 4).

Data Extraction: 2 reviewers independently evaluated studies for eligibility and quality and serially abstracted data. Read more