Initial Lesion Volume Is an Independent Predictor of Clinical Stroke Outcome at Day 90

An Analysis of the Virtual International Stroke Trials Archive (VISTA) Database

Stroke.ahajournals: Gerhard Vogt, PhD; Rico Laage, PhD; Ashfaq Shuaib, MD; Armin Schneider, MD on behalf of the VISTA Collaboration – March 8, 2012.

Abstract

Background and Purpose—Age and National Institutes of Health Stroke Scale early after stroke onset have been identified as important determinants of final stroke outcome. We analyzed the Virtual International Stroke Trials Archive (VISTA) database to define the influence of infarct or hemorrhagic volume on clinical outcome after stroke.

Methods—All patients were extracted from VISTA where infarct or hemorrhage volume information was available (n=2538; most images obtained by CT within 72 hours after stroke onset with a subset of MRI data included, volumes calculated by the ABC/2 approximation method). We used multivariate regression models to study the influence of age, National Institutes of Health Stroke Scale at baseline, and initial infarct/hemorrhage volume on clinical outcome (modified Rankin Scale, National Institutes of Health Stroke Scale, mortality) at day 90. Read More