Melatonin Secretion and the Incidence of Type 2 Diabetes

JAMA: April 03, 2013

Importance  Loss-of-function mutations in the melatonin receptor are associated with insulin resistance and type 2 diabetes. Additionally, in a cross-sectional analysis of persons without diabetes, lower nocturnal melatonin secretion was associated with increased insulin resistance.

Objective  To study the association between melatonin secretion and the risk of developing type 2 diabetes.

Design, Setting, and Participants  Case-control study nested within the Nurses’ Health Study cohort. Among participants without diabetes who provided urine and blood samples at baseline in 2000, we identified 370 women who developed type 2 diabetes from 2000-2012 and matched 370 controls using risk-set sampling. Read more