Metabolic Syndrome Model Definitions Predicting Type 2 Diabetes and Cardiovascular Disease 8/29/12

Metabolic syndrome (MetS) is a cluster of abdominal obesity, hyperglycemia, hypertension, and dyslipidemia, which increases the risk for type 2 diabetes and cardiovascular diseases (CVD). Some argue that MetS is not a single disorder because the traditional MetS features do not represent one entity and would like to exclude features from MetS. Others would like to add additional features in order to increase predictive ability of MetS. The aim of this study was to identify a MetS model that optimally predicts type 2 diabetes and CVD while still representing a single entity.

RESEARCH DESIGN AND METHODS In a random sample (= 1,928) of the EPIC-NL cohort and a subset of the EPIC-NL MORGEN study (= 1,333), we tested the model fit of several one-factor MetS models using confirmatory factor analysis. We compared predictive ability for type 2 diabetes and CVD of these models within the EPIC-NL case-cohort study of 545 incident type 2 diabetic subjects, 1,312 incident CVD case subjects, and the random sample, using survival analyses and reclassification. Read more