Parental consent to participation in a randomised trial in children: Associated child, family, and physician factors

Sage Journals: 7/25/12

Low participation rates in randomised controlled trials involving children are almost a universal problem, leading to high cost and low statistical power. Trial, parent/family, child, and physician factors have been reported to influence parental willingness to consent for paediatric trials.

Purpose To identify modifiable and unmodifiable factors associated with parental consent.

Methods Demographic and clinical characteristics of children and their families and physician characteristics associated with parental consent were evaluated in a recent randomised placebo-controlled trial of prophylactic antibiotics to prevent recurrent urinary tract infection. Read more