Potential of patient-reported outcomes as nonprimary endpoints in clinical trials

Health and Quality of Life Outcomes: May 15, 2013

Background

The purpose of this research was to fully explore the impact of endpoint type (primary vs. nonprimary) on decisions related to patient-reported outcome (PRO) labeling claims supported by PRO measures and to determine if nonprimary PRO endpoints are being fully optimized based on more than 12 years of data.

This review examines the use of PROs as both primary and nonprimary endpoints in support of demonstration of treatment benefit of new molecular entities (NMEs) and biologic license applications (BLAs) in the United States in the years 2000 to 2012.   Read more