Psoriasis and the Risk of Diabetes Mellitus A Systematic Review and Meta-analysis

JAMA Network: 10/15/12

To compare the prevalence and incidence of type 2 diabetes mellitus between patients with psoriasis and those without psoriasis.

Data Sources  MEDLINE, EMBASE, and Cochrane Database of Systematic Reviews between January 1, 1980, and January 1, 2012.

Study Selection  Observational (cohort, case-control, and cross-sectional) studies published in English that compared the prevalence or incidence of diabetes among patients with psoriasis with individuals serving as controls.

Data Extraction  Two independent investigators extracted the data. The quality of evidence was assessed using a 6-point scale.

Data Synthesis  Among 142 identified publications, 27 observational studies were included in the meta-analysis. Five of these studies assessed the incidence of diabetes in patients with psoriasis and were analyzed separately. Among studies assessing the prevalence, psoriasis was associated with an odds ratio (OR) of 1.59 (95% CI, 1.38-1.83) for diabetes.  Read More