Rethinking sources of representative controls for the conduct of case–control studies in minority populations

BMC Medical Research Methodology: May 31, 2013

Background

Recruitment of controls remains a challenge in case–control studies and particularly in studies involving minority populations.

Methods

We compared characteristics of controls recruited through random digit dialing (RDD) to those of community controls enrolled through churches, health events and other outreach sources among women of African ancestry (AA) participating in the Women’s Circle of Health Study, a case–control study of breast cancer. Odds ratios and 95% confidence intervals were also computed using unconditional logistic regression to evaluate the impact of including the community controls for selected variables relevant to breast cancer and for which there were significant differences in distribution between the two control groups.  Read more