Supervised Exercise Program, BMI, and Risk of Type 2 Diabetes in Subjects With Normal or Impaired Fasting Glucose

Diabetes Care: June 11, 2012.


OBJECTIVE
 To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk.

RESEARCH DESIGN AND METHODS Korean subjects (40–79 years) were enrolled (n= 7,233) through the National Health Insurance Corporation who were not diagnosed with diabetes at baseline. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice.

RESULTS During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (n = 5,286) and 83 in the exercise program group (n = 1,947). After adjusting for confounders, the risk of type 2 diabetes was positively associated with BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects.  Read more