The Risk of Long-term Morbidity and Mortality in Patients With Chronic Hepatitis C

JAMA: 11/5/13

Results From an Analysis of Data From a Department of Veterans Affairs Clinical Registry


Importance  The impact of viral load suppression, genotype, race, and other factors on the risk of late-stage liver-related events in patients with hepatitis C (HCV) has been assessed previously using data from small observational cohorts or clinical trials. Data from large real-world practice samples are needed to improve risk factor estimates for late-stage liver events and death in HCV.

Objective  To describe the natural history of HCV in real-world clinical practice.

Design, Setting, and Participants  Observational cohort study. Patients with a detectable viral load (>25 IU/mL) and a recorded baseline genotype were selected from the Veterans Affairs (VA) HCV clinical registry (CCR), which compiles electronic medical records data from 1999 to present. Read more