Timing of Stroke in Patients Undergoing Total Hip Replacement and Matched Controls

AHA Journals: 11/6/12

Background and Purpose—Stroke is a potentially fatal complication of total hip replacements (THR). However, timing of stroke in THR patients compared with matched controls and influence of drug use remain unknown. The objective of this study was to determine timing of stroke in patients with THR compared with matched control subjects.

Methods—A nationwide cohort study was conducted within the Danish registers (1998–2007). Included patients were those with a primary THR in the study period (n=66 583) and were matched by age, sex, and region to three referent subjects without THR or total knee replacements. Time-dependent Cox models were used to derive hazard ratios and were adjusted for disease history and drug use. Read More