Type 2 Diabetes Mellitus and Risk of Incident Atrial Fibrillation in Women ONLINE FIRST

American College of Cardiology Foundation: September 2012
The purpose of this study was to assess whether changes of major atrial fibrillation (AF) risk factors and/or intercurrent cardiovascular events could explain the relationship between type 2 diabetes mellitus (T2D) and incident AF.

Background  Previous studies found an increased risk of incident AF among individuals with T2D, but few, if any, of these studies took into account changes of AF risk factors over time.

Methods  A total of 34,720 female health professionals who participated in the Women’s Health Study, and who were free of cardiovascular disease and AF at baseline were followed for a median of 16.4 years. Cox proportional-hazards models were constructed to assess the relationship between T2D and incident AF, using either information at baseline or time-varying covariates for both T2D and potential confounders. Read more