Urinary Phthalate Metabolite Concentrations and Diabetes among Women in the National Health and Nutrition Examination Survey (NHANES) 2001-2008

Environmental Health Perspectives: 7/13/12.

Background: Previous studies show women to have higher urinary concentrations of several phthalate metabolites compared to men, possibly due to higher use of personal care products. Few studies have evaluated the association between phthalate metabolites, diabetes, and diabetes-related risk factors in women.

Objective: Explore the association between urinary phthalate metabolite concentrations and diabetes among women in a cross-sectional study.

Methods: We utilized data from CDC-analyzed urinary concentrations of phthalate metabolites and self-reported diabetes in 2,350 women ages 20-<80 participating in the NHANES (2001-2008). We used multiple logistic regression to estimate odds ratios (OR) and 95% confidence intervals (CI), adjusting for urinary creatinine, sociodemographic and dietary factors, and body size. A secondary analysis was conducted in women without diabetes to evaluate the association between phthalate metabolite concentrations and fasting blood glucose, HOMA-IR, and hemoglobin A1c. Read more