Weight loss after bariatric surgery reverses insulin-induced increases in brain glucose metabolism of the morbidly obese

ADA Diabetes: March 14, 2013

Obesity and insulin resistance are associated with altered brain glucose metabolism. Here, we studied brain glucose metabolism in twenty-two morbidly obese patients before and six months after bariatric surgery. Seven healthy subjects served as controls. Brain glucose metabolism was measured twice per imaging session: with and without insulin stimulation (hyperinsulinemic euglycemic clamp) using [18F]FDG scanning. We found that during fasting, brain glucose metabolism was not different between groups. Read more